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·edible !
·a crystalline form of calcium phosphate
·as effective as fluoride

Safe A Key Component of the Human Body

Hydroxyapatite is one of our major body components, comprising 60% of bone, 97% of tooth enamel and 70% of dentin. Saliva is also rich in the components of hydroxyapatite, which it supplies to the teeth to replace mineral dissolved by plaque acids, the first step towards tooth decay.By restoring lost mineral, saliva acts to protect against decay in a natural healing process known as ‘remineralization.’ (See)

Biocompatible Used Widely in Dental & Medical Applications

Because it is extremely biocompatible, hydroxyapatite is used in a wide range of medical and dental applications, such as artificial tooth and bone, tissue repair, and coatings to improve the biocompatibility of orthopedic implants. It is also a protein-binding agent, used in chromatography and bacterial culture. In dental applications, hydroxyapatite is sometimes used as an abrasive,depending on its manufactured properties and particle size. However Sangi’s Nano is a non-abrasive, enamel-restorative form of hydroxyapatite approved for its anticaries properties.

Edible! A Dietary Calcium Phosphate Source

Hydroxyapatite is also a rich source of easily digested calcium phosphate, and is used in dietary supplements, remineralizing chewing gum, and as an additive in foods.

Enamel-Restorative An Alternative to Fluoride for Anticaries Use

The influence of fluoride in reducing dental caries has been clearly demonstrated. Its use in drinking water and oral care products dates back over 70 years. Fluoridation has been called the single most effective public health measure to prevent new tooth decay, and early U.S. studies showed it reduced caries among schoolchildren by as much as 35-60%. However excess fluoride can lead to problems such as dental or skeletal fluorosis, and the amount permitted in oral care products and community water systems is controlled.

In contrast, Nano Medical Hydroxyapatite, though not widely known, has been used as a remineralizing agent in toothpaste in Japan for the last three decades. In field trials leading to its approval as an active anticaries ingredient in Japan in 1993, it showed a similar reduction in new caries among schoolchildren to that seen with fluoridation in the U.S., namely 36-56%.

A recent in situ study conducted among healthy adults in the U.S. found that Sangi’s Medical Hydroxyapatite toothpaste not only inhibited development of caries but was not significantly different from fluoride in its ability to remineralize early caries lesions. (Amaechi et al, Remineralization of Early Caries Lesions by Nanohydroxyapatite Dentifrice, now in publication). This supported the findings of earlier in vitro studies in Hong Kong which showed no significant difference in remineralizing effect between fluoride- and Medical Hydroxyapatite ( <mHAP>)-containing toothpastes. Moreover, hydroxyapatite has been shown to be safe, biocompatible – even edible! – and can be swallowed by children without concern, as it has no known toxic or harmful impact.

Remineralization effect of fluoride and toothpastes, by pH cycling
Average increase in new caries using the test toothpaste once daily for 1 year (Group A) and 3 years (Group B)

Fluoride is an element (F-), supplied in the form of compounds such as sodium fluoride (NaF) or sodium monofluorophosphate (NaMFP). It does not replace mineral itself, but strengthens teeth against decay by promoting the uptake of calcium and phosphate from saliva and other sources into the enamel (remineralization), joining in this process to form a new substance, fluorapatite, on the tooth surface, more resistant to plaque acids than the enamel’s original hydroxyapatite. Fluoride is also said to impede bacterial metabolism, helping to lower the level of cariogenic bacteria in the mouth.

In contrast, Nano Medical Hydroxyapatite is a crystalline calcium phosphate substance almost identical to the natural hydroxyapatite of our teeth. Supplied in the form of nanoparticles, it directly replaces lost mineral to restore subsurface demineralized areas of tooth enamel (incipient caries) and fill microscopic fissures on the enamel surface. Its nanoparticles also bind protein such as oral bacteria and plaque fragments during brushing, facilitating their removal from the mouth.

Unlike fluoride, Nano Medical Hydroxyapatite adds nothing ‘new’ to the enamel, but by restoring the enamel’s mineral density and surface smoothness, it increases resistance to bacterial attachment and tooth decay, at the same time enhancing the translucency, gloss and whiteness of the teeth.